关键词: 疼痛模型, 对比分析, 药物研究, 小鼠模型

Abstract: Objective Research, comparison, and analysis of three mouse pain animal models. Method we established and compared three different analgesic mouse models ( acetic acid induced writhing model in mice, formaldehyde induced pain model in mice, and acid induced chronic pain model) to analyze sensitivity, pathological characteristics and drug efficacy evaluating ability. Result In the acetic acid pain model, mice showed significant pain responses, which could significantly evaluate the analgesic effect of neurotropin at 10 times dilution of clinical dose; formaldehyde pain model mice can significantly exhibit both phase I and phase II pain responses, and this model can also significantly evaluate the analgesic effect of neurotropin at 10 times dilution of clinical dose; the mouse model of chronic acid pain exhibits stronger ability to evaluate the analgesic effect, which can significantly evaluate the analgesic effect of neurotropin at 60 times dilution of clinical dose. Conclusion By comparing the pain performance and analgesic efficacy evaluation ability of three different pain mechanism models, the acetic acid pain model and formaldehyde pain model in mice did not show significant differences in analgesic ability evaluation. The selection of the two models can mainly be based on the analgesic mechanism of the drug; the chronic pain model is more sensitive to the response of analgesic drugs and can be prioritized for use in the exploration of analgesic drug dosage.

Key words: analgesic models, comparative analysis, drug research;mouse model